The science Behind Gondola

De Pandis et al, Journal of Neuroengineering & Rehabilitation

Mechanical peripheral stimulation for the treatment of gait disorders in patients with Parkinson's disease: a multi-center, double-blind, crossover randomized controlled trial | Journal of NeuroEngineering and Rehabilitation | Full Text

Advanced-stage multicenter study comparing AMPS with standard therapy for gait disorders in Parkinson's. AMPS proves superior in normalizing rhythm and reducing freezing, with effects persisting for more than a week after the treatment cycle.

Tedeschi R., Clinical Parkinsonism & Related Disorders.

Automated mechanical peripheral stimulation for gait rehabilitation in Parkinson's disease: A comprehensive review - ScienceDirect

Review of 10 RCTs on AMPS: systematically improves speed, step length, stability, and motor parameters in Parkinson's patients, including those with freezing of gait. The review highlights the utility of AMPS as an add-on therapy but stresses the need for further long-term trials and direct comparison with other rehabilitation strategies.

Pagnussat AS et al, Acta Neurologica Scandinavica
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In a randomized study of 25 patients with freezing, 8 AMPS sessions increase brain connectivity between the basal ganglia, insula, and sensory areas. Gait velocity improves and correlates with the increase in connectivity; the neuroplastic mechanism is documented via functional MRI.

Zamuner AR et al, Journal of Hypertension.

Journal of Hypertension

Study highlighting how AMPS improves not only motor parameters but also blood pressure stability in Parkinson's patients with high cardiovascular risk, indicating a potential regulatory effect on the autonomic nervous system.

Galli M et al, Eur J Phys Rehabil Med

Peripheral neurostimulation breaks the shuffling steps patterns in Parkinsonian gait: a double blind randomized longitudinal study with automated mechanical peripheral stimulation - European Journal of Physical and Rehabilitation Medicine 2018 December;54(6):860-5 - Minerva Medica - Journals

AMPS improves spatiotemporal parameters and joint kinematics of gait, particularly breaking the "shuffling" pattern. Effects observed from the first session and progressive up to the sixth.

Kleiner AFR et al, Archives of Physical Medicine and Rehabilitation.
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8 AMPS sessions reduce step variability and asymmetry in patients with freezing, both during simple walking and cognitive dual tasks. The effect is robust and already visible after 4 sessions.

Pagnussat AS et al, Restorative Neurology & Neuroscience.

Plantar stimulation in parkinsonians: From biomarkers to mobility - randomized-controlled trial - Aline Souza Pagnussat, Ana F.R. Kleiner, Carlos R.M. Rieder, Anapaula Frantz, Jaira Ehlers, Camila Pinto, Gilson Dorneles, Carlos Alexandre Netto, Alessandra Peres, Manuela Galli, 2018

AMPS increases BDNF levels (neuroplastic biomarker), lowers cortisol, and improves walking speed and Timed Up & Go performance compared to the sham group and control subjects.

Pinto C et al, American Journal of Physical Medicine & Rehabilitation.
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In the AMPS group, improvements in speed, step length, and hip rotation are observed compared to sham. Effects evident from the first session and consolidated after eight sessions. No relevant adverse events.

Prusch JS et al, Functional Neurology.

AMPS appears safe and well-tolerated; improvements in postural stability are less evident than those in gait but without adverse events.

Barbic F et al, Journal of Applied Physiology.

Effects of mechanical stimulation of the feet on gait and cardiovascular autonomic control in Parkinson's disease | Journal of Applied Physiology | American Physiological Society

Pioneering study on the effects of manual plantar stimulation: one treatment on 16 patients improves speed and step length. Suggests the physiological basis of AMPS.

Stocchi F et al, International Journal of Rehabilitation Research.
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18 patients underwent 6 AMPS sessions every 4 days: significant and lasting improvement in speed, step, and clinical motor scores. Benefits observed up to 10 days after the cycle.

Quattrocchi CC et al, PLoS ONE
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11 patients, functional MRI pre- and post-AMPS or sham: after a single AMPS session, connectivity increases between sensory-motor areas, striatum, and cerebellum; this does not happen with sham.

Kleiner AFR et al, Parkinson's Disease.
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35 patients: stride length +15%, walking speed +15%, propulsion +30%, with more pronounced benefits in a more compromised subjects.

Galli M et al, International Journal of Engineering and Innovative Technology.

(PDF) Timed Up and Go test and wearable inertial sensor: a new combining tool to assess change in subject with Parkinson's disease after automated mechanical peripheral stimulation treatment

Objective technique with wearable sensors: after AMPS, patients perform the TUG faster, improving acceleration and speed in transitional phases and turns.